منابع مشابه
The rise of computational biology
The era of computer simulations (CS) started with the development of the first digital computers in ‘40s and ’50s (for example, MANIAC (stands for “Mathematical and Numerical Integrator and Computer) computer in Los Alamos). First Molecular Dynamics simulations were reported in 1956. Now CS are the standard tool for studying diverse set of problems. The need in CS arises because very few proble...
متن کاملThe EM Algorithm and the Rise of Computational Biology
In the past decade computational biology has grown from a cottage industry with a handful of researchers to an attractive interdisciplinary field, catching the attention and imagination of many quantitatively-minded scientists. Of interest to us is the key role played by the EM algorithm during this transformation. We survey the use of the EM algorithm in a few important computational biology p...
متن کاملDrug discovery in the age of systems biology: the rise of computational approaches for data integration.
The increased availability of large-scale open-access resources on bioactivities of small molecules has a significant impact on pharmacology facilitated mainly by computational approaches that digest the vast amounts of data. We discuss here how computational data integration enables systemic views on a drug's action and allows to tackle complex problems such as the large-scale prediction of dr...
متن کاملRedox Biology on the rise.
Redox reactions are at the heart of bioenergetics, yet their biological role is not restricted to metabolism. One specific focus of contemporary Redox Biology is the study of how the folding, stability, activity, and interactivity of proteins are subject to redox control. Key questions pertain to the chemical nature of physiological redox changes and their exact location inside the cell, the na...
متن کاملQuantitative biology on the rise
This volume marks the third special issue of Molecular Biology of the Cell devoted to quantitative cell biology (QCB). QCB is by no means different from the traditional discipline of cell biology, in the sense that we all are searching for general principles of proteins’ self-organization into molecular machines that make the cell function. On the surface, this task is not that different from t...
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ژورنال
عنوان ژورنال: Ubiquity
سال: 2016
ISSN: 1530-2180
DOI: 10.1145/2892034